retatrutide mechanism triple agonist glp-1 gip glucagon ly3437943 Retatrutide: How GLP-1/GIP/Glucagon Receptor Agonism Differs From Existing Compounds Structural insights into the triple

The secondary structure analysis of the predicted structures (except DrugBank peptides) revealed that the peptide residues frequently belong to loop regions (~32%), followed by helix (~30%), turns (~17%) and bends (~19%)

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Immunogenicity: Because these are peptides, the body can form anti-drug antibodies